Pathophysiological mechanisms of alcoholic myopathy - Lessons from rodent models

Skeletal muscle dysfunction is highly prevalent and one of the earliest pathological tissue changes among people with at-risk alcohol use. Clinical studies to elucidate pathophysiological mechanisms alcohol-mediated disease are hampered due ethical considerations, confounded by nutritional, lifestyle, comorbid conditions. Rodent models have been developed study impact consumption end organ injury, including skeletal dysfunction. This review discusses results from well-established rodent administration highlights key underlying alcoholic myopathy identified in models. Salient pathways include impaired regenerative capacity, altered anabolic/catabolic balance, mitochondrial bioenergetic function, morphological contractile changes.